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Thermo Scientific™ GeneBLAzer™ M4-Gqo5-NFAT-bla CHO-K1 Cells

GeneBLAzer™ M4 Gqo5-NFAT-bla CHO-K1 cells contain the human Acetylcholine (muscarinic) subtype 4 receptor (M4) stably integrated into the GeneBLAzer™ Gqo5-NFAT-bla CHO-K1 cell line.

Brand: Thermo Scientific™ K1741

Product Code. 10703364

16990.00 EUR / Each

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Estimated Shipment: 01-04-2025
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Description

GeneBLAzer™ M4 Gqo5-NFAT-bla CHO-K1 cells contain the human Acetylcholine (muscarinic) subtype 4 receptor (M4) stably integrated into the GeneBLAzer™ Gqo5-NFAT-bla CHO-K1 cell line. GeneBLAzer™ Gqo5-NFAT-bla CHO-K1 cells (Cat. No. K1536) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element and the Chimeric G protein, Gqo5.

The GeneBLAzer™ M4 Gqo5-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC₅₀ concentrations of Cabachol. In addition, GeneBLAzer™ M4 Gqo5-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

The clinical implications of the M4 receptor are unknown, however studies with knockout mice suggest that M4 may have implications in dopaminergic function, karatinocyte migration and wound healing, anxiolysis, and analgesia. In addition, M4 may be important in memory circuits and have implications in Alzheimer's Disease. Additional information on the muscarinic receptors can be found in literature.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.

Specifications

Accession Number	NM_000741
Cell State	Dividing Cells
Description	Population Status: Single Cell Clone Origin
For Use With (Application)	FRET
Includes	GeneBLAzer™ M4 Gqo5 CHO-K1 DA cells, GeneBLAzer™ M4 Gqo5 CHO-K1 DA Assay Protocol, Certificate of Analysis, Solution D, LiveBLAzer™-FRET B⁄G Loading Protocol
Product Line	GeneBLAzer™
Reporter Gene	BLA (Beta-Lactamase)
Type	Dividing Cells
System Type	GeneBLAzer™

Assay Entry	Cell-based beta lactamase reporter gene
Content And Storage	LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol. Includes: • GeneBLAzer™ M4 Gqo5 CHO-K1 DA cells • GeneBLAzer™ M4 Gqo5 CHO-K1 DA Assay Protocol • Certificate of Analysis • Solution D • LiveBLAzer™-FRET B/G Loading Protocol The GeneBLAzer™ M4-Gqo5-NFAT-bla CHO-K1 cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
Detection Method	Fluorescence
Gene Symbol	M4
Population Status	Single Cell Clone Origin
Quantity	2 x 10⁶ Cells
Target Entry	M4
Cell Line	CHO-K1
Druggable Target	GPCR

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Lot Number	Certificate Type	Date	Catalog Number
Lot Number36896	Certificate TypeCertificate of Analysis	Date16/04/2017	Catalog NumberK1741

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Thermo Scientific™ GeneBLAzer™ M4-Gqo5-NFAT-bla CHO-K1 Cells

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