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Eurofins DiscoverX Raf-1 Protein, Active

Active, N-terminal GST-tagged recombinant human Raf-1 residues 306-end, containing the mutations Y340D and Y341D, for use in Kinase Assays.

Brand:  Eurofins DiscoverX 14-352M

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Product Code. 17310164

  • 4008.15 EUR / 250µg

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Description

Description

Raf-1 is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

EMBL X03484

Specifications

Specifications

mg/mL of enzyme in 50 mM Tris/HCl, pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
250 μg
Recombinant
Recombinant enzyme expressed in Sf21 insect cells
≥60%
65 kDa
Human
N-terminal GST
Truncated
Raf-1 (truncated), active
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