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Eurofins DiscoverX Raf-1 Protein, Active

Active, N-terminal GST-tagged recombinant human Raf-1 residues 306-end, containing the mutations Y340D and Y341D, for use in Kinase Assays.

525.15 EUR - 4008.15 EUR

Specifications

Formulation	mg/mL of enzyme in 50 mM Tris/HCl, pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molecular Weight (g/mol)	65 kDa
Species	Human
Recombinant	Recombinant
Protein Tag	N-terminal GST

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Products 2

Product Code	Brand	Quantity	Price	Quantity & Availability
Product Code	Brand	Quantity	Price	Quantity & Availability
17300164 View Documents missing translation for 'viewProductCertificates'	Eurofins DiscoverX 14-352	10 μg	525.15 EUR 10µg View alternative products Save Up to »		Please sign in to purchase this item. Need a web account? Register with us today!

17310164 View Documents missing translation for 'viewProductCertificates'	Eurofins DiscoverX 14-352M	250 μg	4008.15 EUR 250µg View alternative products Save Up to »		Please sign in to purchase this item. Need a web account? Register with us today!

Description

Raf-1 is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

EMBL X03484

Specifications

Formulation	mg/mL of enzyme in 50 mM Tris/HCl, pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Species	Human
Protein Tag	N-terminal GST
Protein Form	Truncated
Protein	Raf-1 (truncated), active

Molecular Weight (g/mol)	65 kDa
Recombinant	Recombinant
Expression System	Recombinant enzyme expressed in Sf21 insect cells
Purity or Quality Grade	≥60%

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Eurofins DiscoverX Raf-1 Protein, Active

Specifications

Description

Specifications

Documents